Research Associate II/ Senior Research Associate, In Vitro Pharmacology

Who Are We?

Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation. Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously. We are further evolving the platform and leveraging its strengths to address unmet medical needs.

We are looking for exceptional team members who want an active role in building a rapidly growing biotech.

Title: Research Associate II/ Senior Research Associate, In Vitro Pharmacology Location: South San Francisco, CA Department: Therapeutics Reports To: Principal Scientist, Pharmacology and Bioanalytical Development

Opportunity:

We are seeking an exceptional Research Associate II or Senior Research Associate to join our In Vitro Pharmacology team. In this role, you will help advance CRISPR-based epigenetic therapies from discovery through preclinical development, with a focus on neuromuscular and rare genetic diseases. This position is ideal for a highly motivated scientist who enjoys hands-on experimentation, critical data analysis, and scientific problem-solving in a fast-paced biotechnology environment, with the opportunity to take increasing ownership of projects and grow into more independent scientific roles.

Position Summary:

In this role, you will design and execute in vitro studies to characterize the activity, potency, mechanism of action (MoA), and translational potential of CRISPR-based gene regulation therapeutics. The ideal candidate brings hands-on expertise in molecular and cellular biology, gene editing technologies, and disease-relevant cellular models. Experience in neuromuscular disease biology, gene therapy, or epigenetic regulation is highly desirable.

Key Responsibilities:

• Design, execute, analyze, and interpret in vitro pharmacology experiments that support therapeutic candidate discovery and advancement.
• Develop and optimize cellular assays to evaluate CRISPR-based epigenetic editing systems, including potency, durability, specificity, and mechanism of action, to inform program decisions.
• Generate high-quality datasets and apply rigorous analysis to support data-driven program decisions.
• Partner closely with cross-functional teams to advance therapeutic programs.
• Culture, engineer, and characterize mammalian cell lines, primary cells, and iPSC-derived d