Principal Process Engineer

COMPANY DESCRIPTION:

A career here is life-enhancing.

At Syner-G, we enable our people to build careers that impact positively on their quality of life. Through our expertise, insight, consulting and management skills, we accelerate breakthrough science and delivery of life-enhancing therapies to more patients. We work across a diverse range of clients and projects, supporting many organizations from the most critical phases of the drug discovery and approval process through to commercialization. It is meaningful, varied and thought-provoking work with a strategic emphasis, a solutions-driven approach and significant, real-world outcomes, from science to delivery/success. To learn more about who we are and what drives us, watch our company video here .

Underpinning this mission is a culture that aligns perfectly with what we want to achieve. We enable our people to grow, we support them in their learning and we reward them in so many different ways. In return, they play an instrumental role in maintaining our reputation across the globe as a strategic biopharma product development and delivery partner.

Syner-G was recently honored with BioSpace's prestigious "Best Places to Work" 2026 award, for the third consecutive year, along with many other award-winning programs to make a career here truly life-enhancing. These recognitions are a testament to our commitment to fostering a positive and engaging work environment for our employees, with a particular emphasis on culture, career growth and development opportunities, financial rewards, leadership and innovation.

At Syner-G, we recognize that our team members are our most valuable asset. Join us in shaping the future, where your talents are valued, and your contributions make a meaningful impact.

For more information, visit www.Synergbiopharma.com

POSITION OVERVIEW:

Syner-G is seeking a Principal Process Engineer with 18+ years of experience to provide strategic technical leadership in the design, optimization, and automation of complex manufacturing and laboratory processes. This role serves as a senior technical authority responsible for shaping long-term process strategy, leading major engineering and automation initiatives, and driving innovation across multiple client programs. The Principal Process Engineer will guide cross-functional teams, mentor engineering staff, and ensure the development of highly robust, scalable, and efficient processes that support development, clinical, and commercial operations.

WORK LOCATION:

Travel to client sites may be required up to 100%, based on project demands and client expectations.

KEY RESPONSIBILITIES:

(This list is not exhaustive and may be supplemented or changed as necessary.)

• Lead enterprise-level process development, optimization, and scale-up initiatives across upstream, downstream, or formulation operations.
• Serve as a senior technical authority for process automation strategy, including advanced control methodologies, digital transformation, and integration of next-generation technologies.
• Develop, review, and approve complex engineering documentation such as PFDs, P&IDs, engineering studies, equipment specifications, and process descriptions.
• Conduct high-level process modeling, statistical analysis, and system-wide assessments to drive strategic improvements and long-term process reliability.
• Lead commissioning, qualification, and startup of major process systems, automated equipment, and integrated manufacturing platforms.
• Partner with automation, engineering, operations, and digital teams to implement advanced monitoring tools, predictive analytics, and data-driven process control solutions.
• Troubleshoot critical process deviations, equipment failures, and automation issues, providing expert-level guidance to engineering teams and client stakeholders.
• Lead multi-site technology transfer activities, ensuring process scalability, consistency, and alignment across development, clinical, and commercial environments.
• Oversee vendor relationships and manage complex equipment upgrades, process redesigns, and automation projects with significant technical and business impact.
• Drive continuous improvement initiatives focused on yield, throughput, cost efficiency, and long-term process robustness.
• Mentor, coach, and develop engineering staff at all levels, contributing to organizational technical capability and succession planning.
• Advise internal leadership and client executives on process strategy, risk mitigation, and long-term technical planning.
• Influence organizational engineering standards, best practices, and technology roadmaps.

QUALIFICATIONS AND REQUIREMENTS:

Education

• BS/MS in Chemical Engineering, Mechanical Engineering, Bioprocess Engineering, or a related technical field preferred.

Experience

• 18+ years of experience in process engineering within biotech, pharmaceutical, or advanced manufacturing environments.
• Extensive experience with automated process equipment such as bioreactors, chromatography systems, filtration skids, or formulation systems.
• Deep expertise with process automation platforms (e.g., DeltaV, Rockwell, Siemens, SCADA/PLC systems).
• Demonstrated leadership in process development, scale-up, equipment integration, and process optimization across multiple programs or sites.
• Proven ability to lead cross-functional teams, manage complex technical programs, and mentor engineering staff.
• Experience shaping process strategy, influencing technical direction, and contributing to long-term operational planning.

Technical Skills

• Expert-level understanding of process engineering fundamentals, mass/energy balances, process control, and equipment design.
• Strong ability to develop, interpret, and approve P&IDs, engineering drawings, and automation logic.
• Advanced data analysis and modeling capabilities using engineering and statistical tools.
• Excellent communication, leadership, and program management skills.
• Ability to manage multiple high-priority initiatives in a fast-paced, technically demanding environment.

ESSENTIAL