Manager/Sr. Manager, Patient Supply Operations

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Legend Biotech is seeking a Manager/Sr. Manager, Patient Supply Operations as part of the Patient Supply Strategy & Operations team based in Somerset, NJ .

Role Overview

Legend Biotech is seeking an experienced and driven Manager/Sr. Manager- Patient Supply Operations to join our Technical Development team. This role will report to the Director of Patient Supply Strategy & Operations and be responsible for supporting hands on execution of global patient supply activities for early clinical Cell and Gene Therapy programs (Allogenic and In-Vivo). This role is accountable for operational readiness of investigational product supply from IND through First-In-Human and early Phase studies, in alignment with regulatory requirements. The successful candidate will translate clinical and CMC needs into executable supply plans, ensure compliant distribution, inventory control, and QP release, and partner cross functionally to enable uninterrupted delivery of product to global clinical sites. This is a hands-on role requiring strong ownership of execution, vendor oversight, accountability, independent issue resolution in a fast-moving early phase environment.

Key Challenges

• Building global supply chain infrastructure in an early-phase, rapidly evolving environment.
• Executing first-time country start-ups, particularly in ex-US regions with regulatory requirements.
• Managing import/export processes and IOR/EOR models across multiple countries.
• Ensuring reliable delivery of temperature-sensitive products (LN2, -80°C).
• Responding to real-time logistics issues while maintaining compliance and timelines.

Key Deliverables

• Execution of FIH and early-phase global clinical shipments.
• Establish global depot and logistics network, including ex-US infrastructure.
• Define and implement import/export workflows and IOR/EOR models.
• Execute per country-specific clinical supply playbooks and SOPs.
• Operational cold-chain distribution lanes with defined performance metrics.

Key Responsibilities

• Own and execute global patient supply for early‑phase programs, aligned with clinical development plans and evolving protocol requirements as per program strategy.
• Operationalize bulk vs. per‑patient distribution strategies, safety stock policies, and contingency plans.
• Assist in developing supply manuals and SOPs for global clinical distribution including country specific clinical supply playbooks covering labeling, distribution, and inventory models.
• Support Label design for primary and secondary packaging for the drug products in compliance with regional requirements.
• Manage end-to-end global shipments including pr